The drug acts on the sensory receptors of the trigeminal nerve in the middle nasal passage and cause reflex secretion in the mucosa of the nasal cavity and the proviron. Stimulated secretion of mucous-purulent nasal cavity after dosing begins and lasts 30-60 minutes, depending on the individual. Hypersecretion is accompanied by increase in inflammatory exudate, changes in the rheological properties of secretions and further normalization of its viscosity. Reflex hypersecretion in combination with anti-edematous effect of the drug leads to secretion evacuation of the sinuses in the nasal passages, and provides the physiological drainage of the sinuses at the same time. The drug helps restore the mucociliary transport in the nasal cavity and the , by increasing the presence of liquid in the surface layer of the mucus secretion. Sinuforte enhances blood microcirculation in the mucosa of the nose. This is due to the fact that the parasympathetic stimulation, which activates the secretion also causes vasodilation of blood vessels that supply cancer.
The is due to the combined effect of the components of cyclamen, the most studied of which are triterpenoidosoderzhaschie saponins. Conduct kinetic studies is not possible, because all the components can be tracked using markers or research. For the same reason it is impossible to detect and drug metabolites.
- Acute and chronic sinusitis;
- The period of early postoperative rehabilitation after endoscopic surgery of the paranasal sinuses
- Hypersensitivity to the drug;
- Polypoid rhinosinusitis;
- Allergic rhinosinusopathy;
- Acute allergic reactions in the face and neck;
- Hypertension II-III degree;
- Children proviron under the age of 12 years (due to lack of experience of the children of primary school and pre-school age)
There may be a sense of light or moderate burning sensation in the nasal cavity, salivation and / or watery eyes in response to stimulation of sensory receptors of the trigeminal nerve.
In some cases it may be redness of the face, a brief headache in the frontal region or appear colored in pale pink color discharge from the nose as a result of capillary diapedesis. The above short-term physiological responses confirm the reflex mechanism of action of the drug and are not an indication for its abolition.
Currently, the cases of drug overdose have been reported. Excess single dose does not increase the therapeutic effect and may cause severe burning sensation and pain in the nasopharynx. If there is an overdose of symptoms should be rinsed with lukewarm water nasal cavity and a symptomatic therapy.
Use during pregnancy and lactation
The drug is not recommended for use during pregnancy and breastfeeding due to lack of experience applying under these conditions.
Interaction with other drugs
It is necessary to refrain from pre-injection and simultaneous use of local anesthetics and / or topical decongestants and preparation for a possible violation of the mechanism of action of the drug proviron.
If necessary, possible and permissible combinations with antibacterial drugs.
Interactions with other drugs has not yet been studied.
During the administration of the drug is recommended to hold your breath.
Direct spraying of the drug should be carried out at the touch of a vertical position of the head.
Before applying are encouraged consultation, doctor.
Valium for drug of a solution for intranasal administration. 50 mg vial made of colorless glass (hydrolytic class 1, EF), a sealed rubber stopper of type proviron with a screwed plastic cap.
Dry lyophilisate should be stored in a dark place at a temperature no higher than 25 ° C.
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Ready-to-use preparation (diluted lyophilisate) should be stored at temperatures between 2 and 8 ° C for 15 days in a dark place.
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