The dose and mode of administration of the drug, as well as the duration of treatment established by the attending physician depending on the concentration of glucose in the blood plasma. Monotherapy The recommended starting dose is 1-2 times a day during or after a meal. after 10-15 days after initiation of drug may further gradual increase in the dose depending on the glucose concentration in the blood plasma, to an average daily. The gradual increase in the dose improves the tolerability of the gastrointestinal tract. The maximum dose is a day in 3 divided doses. For patients who are prescribed high may be replaced two tablets of the proviron libido. in the case of a patient transfer to treatment with other antidiabetic therapy medicinal product, discontinue use of the latter and to start taking at the doses described above.
Because of the possible violations of renal function in elderly patients dose proviron libido are selected based on the concentration of creatinine in the blood plasma. The need for regular assessment of renal function.
Children from 10 to 18 years of monotherapy and combined use with insulin standard starting dose is 500 mg proviron libido 1 time per day during or after a meal. After 10-15 days after receiving the drug may further gradual increase in dose depending on the glucose concentration in the blood plasma. A gradual increase in the dose of the drug improves the portability of the gastrointestinal tract. The maximum dose for children is daily in 2-3 doses. The dose of insulin is determined based on plasma glucose concentration.
Possible side effects when using the drug are listed below in descending frequency of occurrence: , very rare (<1/10000), including isolated reports. nervous system: Common: taste disturbance. From the digestive system: very common: nausea, vomiting, diarrhea, abdominal pain, loss of appetite, “metal “taste. These undesirable effects often occur at the beginning of therapy and in most cases are spontaneously. To prevent symptoms of the dose is recommended to distribute to 2-3 doses during or after meals. A gradual increase in dose improves the tolerability of the drug from the gastrointestinal tract. For the skin: Very rare: Skin proviron libido reactions such as redness, itching, urticaria. Metabolism: Very rare: Lactic acidosis (requires discontinuation of treatment). With prolonged use a decrease in the absorption of vitamin B 12 and reduced its plasma concentration. This should be considered if the patient megaloblastic anemia. Violations of the liver and zhelchevyvodyashih ways: Individual messages: reversible liver function abnormalities lead to increased activity of “liver” transaminases, hepatitis B or going after you stop taking metformin.