Paroxetine is well absorbed after oral administration proviron hair loss and undergoes first pass metabolism through liver. Isolation from urine unchanged paroxetine is generally less than 2% of the dose, and metabolites constitute about 64% of the dose. Intestine excreted about 36% of the dose, probably via the bile, which is unchanged paroxetine less than 1% of the dose. Thus, paroxetine is derived mainly from the metabolism. Excretion of metabolites paroxetine body 2 phase, a first result of the first pass metabolism through the liver, and then it is controlled systemic elimination.
Half-life varies, but is typically about one day. Stable systemic concentrations are achieved in 7-14 day after the start of treatment, and the pharmacokinetics does not change during long-term treatment. Clinical effects of paroxetine (side effects and effectiveness) are not correlated to its concentration in plasma. Since metabolism paroxetine comprises the step of first passage through the liver, the amount determined in the systemic circulation is less than that which is absorbed from zhedudochno – intestinal tract. By increasing the dose of paroxetine or multiple dosing is increased when the load on the body, partial absorption effect of the first “pass through the liver” and reduced plasma clearance of paroxetine. As a result, possible improvement of paroxetine concentrations in plasma and vibrations pharmacokinetic parameters that can be observed only in those patients who when receiving low doses reach low levels of drug in plasma. Paroxetine proviron hair loss is extensively distributed in tissues, and pharmacokinetic calculations indicate that only 1% of its present in plasma, and the therapeutic concentrations in 95% bound to plasma proteins. in elderly patients and in severe hepatic and renal failure, in the plasma concentration of paroxetine improved, and the range of plasma concentrations practically coincides with the range in healthy adult volunteers.
– Depression of all types, including reactive, severe endogenous depression and depression accompanied by anxiety;
– obsessive-compulsive disorder (OCD)
– panic disorder, including agoraphobia;
– social anxiety disorder / social phobia;
– generalized anxiety disorder.
– Hypersensitivity to the drug, including sucrose;
– simultaneous reception of inhibitors in the 14 days after their cancellation;
– unstable epilepsy;
– pregnancy and lactation
– Children under 18 years old.
Precautions: hepatic impairment; renal failure; angle-closure glaucoma; prostatic hyperplasia; mania; Pathology of the heart; epilepsy; convulsive conditions; appointment of cardioversion; taking medications that increase the risk of bleeding; the presence of risk factors proviron hair loss for increased bleeding and disorders that increase the risk of bleeding.
Dosing and dose
vial equipped with dispensing pipette lid calibrated to retrieve 0.5 ml, 1 ml, 1.5 ml, 2 ml of solution corresponding to 10, 20, 30, 40 drops, respectively.
1 ml of solution corresponding to 20 drops, which is equivalent to 10 mg of paroxetine.
One drop corresponds to 0.5 mg of paroxetine.