When a large overdose proviron dosage may develop lactic acidosis, symptoms are severe weakness, respiratory disorders, drowsiness, nausea, vomiting, diarrhea, abdominal pain, hypothermia, lowering blood pressure, reflex bradyarrhythmia. May include the muscle pain, confusion and loss of consciousness. With the development of lactic acidosis is suspected, it is recommended the immediate withdrawal of the drug and emergency hospitalization.
The most effective method to remove lactate and metformin from the body – hemodialysis.
Interaction with other medicinal products Concomitant use contraindicated Iodinated contrast agents Intravascular administration of iodinated contrast agents in patients with diabetes may be complicated by renal failure, resulting in metformin accumulates and increases the risk of lactic acidosis. Use of the drug Siofor ® 500 should be canceled 48 hours in advance and proviron dosage not to resume earlier than 2 days after the X-ray studies using iodinated contrast agents under normal serum creatinine concentration. Concomitant use not recommended Alcohol and etanolsoderzhaschie drugs The risk of lactic acidosis increases with acute alcohol intoxication or the simultaneous use of ethanol-containing preparations, especially against the background of fasting or eating disorders, and liver failure. simultaneous use requires caution Concomitant use of metformin with danazol may lead to the development of hyperglycemia effect. If necessary, treatment with danazol and after termination of application required dose metformin correction under the control of plasma glucose concentration. In an application with oral contraceptives, epinephrine, glucagon, thyroid hormones, phenothiazine derivatives, nicotinic acid may increase the concentration of glucose in the blood plasma. Nifedipine increases absorption, the maximum concentration in the blood plasma metformin, prolongs its elimination.
Cationic drugs (amiloride, morphine, procainamide, quinidine, hiniin, ranitidine, triamterene, vancomycin) secreted in the tubules, compete for tubular transport system and long-term therapy can increase the maximum concentration of metformin in serum. Cimetidine slows the excretion of the drug, resulting in increased risk of developing lactic acidosis. Metformin reduces the maximum concentration and half-life of furosemide; may weaken the effect of indirect anticoagulants. Glucocorticoids (systemic and local application), beta-agonists, and diuretics have hyperglycemic activity. It should more carefully control the plasma glucose concentration, especially at the beginning of treatment. If necessary, the dose of metformin should be adjusted for the period of simultaneous application, and after withdrawal of these drugs.
Proviron dosage inhibitors and other antihypertensive drugs can reduce plasma glucose concentration. If necessary, the dose of metformin can be adjusted. With the simultaneous use of the drug Siofor ® 500 with a sulfonylurea, insulin, acarbose, salicylates may increase hypoglycemic effect.