Because the use of tizanidine controlled studies in pregnant women have not been conducted, it should not be used during pregnancy except in cases where proviron buy the potential benefits outweigh the possible risk.Tizanidine is excreted in breast milk in small amounts, however, women, nursing child feeding, the drug should not be used.
Dosing and Administration
The drug is prescribed inside. Dosage should be adjusted individually. When painful muscle spasm Sirdalud administered at a dose of 2 mg or 4 mg three times a day. In severe cases bedtime can additionally take 2 mg or 4 mg. When spasticity of skeletal muscle due to neurological diseases, the dose should be adjusted individually.
The initial daily dose should not exceed 6 mg, divided into 3 doses. The dose may be increased gradually at 2-4 mg, at intervals of 4.3 to 7 days. Usually the optimal therapeutic effect is obtained at a daily dose of 12 to 24 mg, divided into 3 or 4 doses at regular intervals. Do not exceed a dose of 36 mg per day.
Use in patients with renal insufficiency
treatment of patients with renal insufficiency (creatinine clearance less than 25 mL / min) is recommended to start with 1 dose of 2 mg once a day. Increasing doses carried small “steps”, in view of tolerability and efficacy. If necessary a more pronounced effect, it is advisable to increase the first dose to be assigned to one time per day, then increase the multiplicity of purposes.
Adverse reactions are distributed in accordance with the frequency of occurrence. The following criteria are used to evaluate the incidence of adverse reactions: very common); very rare (<1/10000), including isolated reports. From the nervous system: often – drowsiness, dizziness; -gallyutsinatsii rarely, insomnia, sleep disorder.
Since the cardiovascular system: often – bradycardia, low blood pressure.
From the gastrointestinal tract: often – dry mouth; rarely – nausea, gastrointestinal disorders.
Liver: rare – increase in liver transaminases, very rarely – hepatitis.
From the musculoskeletal system: rarely – muscle weakness proviron buy.
Other: often – fatigue.
At lower doses, recommended for relief of painful muscle spasms, marked drowsiness, fatigue, dizziness, dry mouth, decreased blood pressure , nausea, gastrointestinal disorders, elevation of liver transaminases. Typically, the above adverse reactions are mild and transient.
At higher doses recommended for the treatment of spasticity, the above side reactions are more and more pronounced, however, are rarely so severe that the treatment had to be interrupted. In addition, you may experience the following effects: decreased blood pressure, bradycardia, muscle weakness, insomnia, sleep disturbances, hallucinations, hepatitis.
To date, we received a few reports of overdose sirdalud, including the case where the dose taken was 400 mg. In all cases, recovery was uneventful.
Symptoms: nausea, vomiting, decreased blood pressure, dizziness, drowsiness, cramps, anxiety, respiratory failure, coma.
Treatment. Multiple appointment of activated charcoal is recommended for the excretion of the drug. Forced diuresis also may accelerate proviron buy the excretion sirdalud. Subsequently, symptomatic treatment. parbol