Nandrolone (19-testosterone), related to anabolic steroids, was synthesized in the fiftieth year of the last century. The structure of all anabolic androgenic steroids is similar to the structure of testosterone (the male sex hormone). However, artificial analogs are much more effective in building muscle mass (anabolic effect). Nandrolone – a classic representative of anabolic. The conducted studies have proved that the time of action on cellular receptors, which play an important role in the course of anabolic processes, it surpasses substances having a similar formula. This was the reason for the success of nandrolone. In Hungary, nandrolone decanoate was produced under the name “Retabolil”. In the US and Western countries, it is known as the Deca-Durabolin. In one ampoule, retabolil contains fifty milligrams of active substance. The effect after the application of nandrolone is maintained for two weeks. The properties of nandrolone determine its use in recovery after trauma, treatment of dystrophy, postoperative and post-infarction periods. If the drug enters the female body, an increase in hemoglobin is observed, a decrease in bone calcium loss. People, whose activities are associated with constant physical exertion (artists of circus, ballet), a busy work schedule (the stars of show business), the course of injections is sometimes necessary and becomes an exit from a difficult situation. Many doctors, biologists, physiologists consider the concept of the IOC (International Olympic Committee), which declared a real war against doping, wrong and to some extent criminal. The fact is that the ban on Nandrolone by this organization, supposedly standing guard over the health of athletes and fair competitions, leads the athletes to search for alternative options that involve using less studied drugs that are more toxic and harmful to health.
Properties of nandrolone
The structural difference between nandrolone and testosterone is the absence of the first methyl group in the molecule, 19 which caused the spread of the name 19-nortestosterone. This gave the substance the ability to better stabilize androgen receptors. In other words, the action time of nandrolone increases approximately two to three times compared with the time of action of testosterone, and the longer the receptor remains activated, the more protein is synthesized by the cell. There is also a negative point: free nandrolone degenerates into dihydronandrolone (DHN), which is two to three times less effective than nandrolone, worsens the ability of nerve fibers to transmit signals, which negatively affects neuromuscular stimulation and libido. However, nandrolone is not so active in the prostate, skin, so athletes who take this drug, are less prone to acne, prostate hypertrophy, baldness.
The effect of aromatase on the course of nandrolone is not so significant. But as a result of the chemical reaction, estrogen is still produced, albeit in small amounts. Do not forget about the progestogenic activity of 19-nortestosterone. Those who have a total dose of the drug exceed six hundred milligrams per week, expose themselves to the risk of developing gynecomastia.
The choice of the method of using the drug is due to genetic differences. For some, nandrolone is simply a miracle cure. Others, whose body interacts badly with the “long esters” of Nandrolone, risk becoming ill with health problems. This result is due to the presence in the muscle fibers of a large amount of 5-alpha-reductase, when it is possible to replace 19-nortestosterone with phenylpropionate, or hypersensitivity to progesterone. In the second case, a way out of the situation in using nandrolone along with stanazolol or preventing excess of a weekly dose of over three hundred to four hundred milligrams. Athletes who do not have the above features, the use of nandrolone will greatly facilitate the collection of mass. The use of testosterone and nandrolone in the activation of satellite cells and the increase of IGF-1, stimulating muscle hyperplasia, but the dosage of the latter should exceed six hundred milligrams per week. Based on the properties of nandrolone, capable of retaining water, its use during the “drying” before the competition is inexpedient.
Previously, it was believed that the retention of fluid in the body under the influence of nandrolone is one of the factors in the accumulation of water in the articular bags, which makes the joints feel beneficial. In fact, the mechanism of functioning of 19-nortestosterone is somewhat more complicated.
The drug does not cause additional water flow into the joint bags. Thanks to the nandrolone, the water simply does not leave them. This process is explained by the fact that nandrolone is a very strong progestin, possessing a fifth of progesterone capacity, and can be converted to estradiol, responsible for water retention in tissues. Assessing the properties inherent in nandrolone, one can not but note its superiority over other drugs that have antiestrogenic (drostanolone) and antiprogestagen (stanozolol) activity. Creation of a cycle of trenbolone, stanozolol, drostanolone can become a factor of causing harm to the joints in the intense training process. Do not forget: if a certain concentration of estrogens and progestins is exceeded in the blood plasma, an anti-inflammatory effect is observed. Nandrolone has progestagenic activity, the ability to convert to estradiol, which determines the possibility of beneficial effects on joints. In this respect, nandrolone is much superior, oxymetholone, methandrostenolone, testosterone.
Nandrolone not only affects the increase in muscle mass. At its reception power indicators grow considerably. Most athletes, whose weekly dose is not less than four hundred milligrams, confirm this. However, there is one very important negative factor: the inhibition of the production of endogenous testosterone by 19-nortestosterone leads to a worsening of the conductivity of nerve fibers and a violation of erectile function. Not everyone is ready to sacrifice their intimate life. The way out is seen in the use in conjunction with nandrolone of a strong androgen, for example, testosterone.
When using the deck, there are usually no serious side effects. However, when the weekly dosage exceeds four hundred milligrams, blood pressure often rises. Against the background of deterioration of blood coagulability, this leads to nasal bleeding, poor healing of wounds, work of sebaceous glands in forced mode, acne, severe headaches. The maximum increase in dose is fraught with a disruption in the testicles, which begin to produce less testosterone, which causes a delay in the release of the gonadotropins by the pituitary gland.
High progestagenic activity of nandrolone leads to erectile dysfunction and gynecomastia.
Achieving a noticeable effect of taking nandrolone is possible at dosages of two hundred milligrams a week or more. Some professional level athletes prescribed a daily dose of eight hundred milligrams. As far as it is reasonable in our days, it’s hard to say. After all, there has recently been a tendency to abandon the nandrolone decanoate. Bodybuilders of the world level, consider this drug exhausted and morally obsolete. However, people who do not think about sports achievements and just want to have a beautiful body can be advised to set an upper limit for themselves in one gram of nandrolone per week.
Nandrolone decanoate has a fairly long half-life, so it is advisable to stay on one injection a week. True, there is another opinion. Many believe that to maintain a stable level of the hormone, long-lived drugs are more likely to be injected into the body.
How to combine the deck with other steroids
It is not so often possible to meet people who have chosen nandrolone as the only steroid in the cycle. Rather, it is the lot of testosterone and trenbolone. Usually, drugs that are synergists are combined. The scheme of taking nandrolone with methandrostenolone is considered to be effective. Even greater efficiency is achieved by those who include testosterone (the ratio of nandrolone and testosterone 1: 2) in a complex with nandrolone. The second method is also a kind of insurance against the emergence of problems with potency. The combination of the three drugs listed above – the best option for those wishing to gain weight in the shortest time.
It is worthwhile to caution the zealous followers of dubious ideas, taking on faith everything they are told. The use of nandrolone with other progestins (anapolone, trenbolone) is dangerous and can lead to negative consequences, to cause the refusal of anabolic steroids for a long time.
Application of the deck by women
In the middle of the last century, nandrolone found wide application in the treatment of women. And representatives of traditional medicine considered it a fairly effective drug. Then on 19-nortestosterone drew attention athletes and actively used it until the nineties, while research conducted by Heinonen and Gusens, did not cast a shadow on the drug. The first experiment consisted of taking nandrolone decanoate women fifty milligrams every three to four days. As a result, half of the subjects began to observe the phenomenon of virilization. The second experiment did not lead to this. However, nothing was reported about the dose. Of course, women’s intake of one hundred milligrams of nandrolone decanoate per week raises questions, but a dose restriction of thirty milligrams administered once every two weeks can be considered acceptable. This fact was proved by an experiment that took place in 1996, when such a method of reception of the phenomena of virilization was not recorded. Dear ladies, still choosing the deck as a means to achieve the goal, I want to advise not to rush to extremes and start with a dose of fifty milligrams once every ten days, gradually increasing it to seventy-five to one hundred milligrams in the same period of time. The first signs of virilization should become a signal to stop taking the drug.