The main point of application, its action is in the spinal cord. Stimulating presynaptic alpha2-receptors, it suppresses the release of excitatory amino acid receptors which stimulate the buy proviron online . Consequently, at the intermediate neurons of the spinal cord is suppressed polysynaptic transmit excitation. Since this mechanism is responsible for excessive muscle tone, the muscle tone decreases in its suppression. In addition to the muscle relaxant properties, tizanidine also exerts a central Moderate analgesic effect.
Sirdalud effective both in acute painful muscle spasms and chronic spasticity of spinal and cerebral origin. It reduces spasticity and clonic convulsions, thereby reducing the resistance to passive movements and increases the amount of active movements.
Tizanidine absorbed rapidly and almost completely. Maximum plasma concentration (Cmax) is achieved after about 1 hour after ingestion. Due to the pronounced metabolism in the “first pass” through the liver is the average value of bioavailability is about 34%.
The average value of the volume distribution during the equilibrium state of the drug when administered intravenously is 2.6 l / kg. Plasma protein binding is 30%.In the dose range from 4 to 20 mg tizanidine pharmacokinetics is linear. Given the low inter-individual variability of pharmacokinetic parameters (in particular, such as , while taking into tizanidine can reliably predict the value of its concentration in plasma. Gender does not affect the pharmacokinetic parameters of tizanidine.
It was shown that quick and tizanidine largely metabolized in the liver. In vitro it was shown that tizanidine is mainly metabolized isoenzyme of cytochrome buy proviron online. The metabolites are inactive.
The mean value of the half-life of tizanidine from the systemic circulation is 2-4 h drug excreted mainly by the kidneys (approximately 70% of dose) in the form of metabolites.; the share unchanged substance accounts for about 2.7%.
Pharmacokinetics of certain groups of patients
has been found that in patients with renal impairment (creatinine clearance less than 25 mL / min), the average value of Cmax is 2 times higher than that in healthy volunteers, and the terminal half-life was prolonged to about 14 hours, whereby AUC increased an average of 6 times.
Effect of food
Simultaneous food intake does not affect the pharmacokinetics of tizanidine. Although Cmax value increases to 3.1, it is considered that it is not clinically significant. No significant effect on absorption is not marked.
Painful muscle spasms:
- associated with static and functional disorders of the buy proviron online spine (cervical and lumbar syndromes);
- after surgery, for example, for a herniated intervertebral disc or osteoarthritis of the hip joint.
Spastichnost skeletal muscles in neurological diseases such as multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, the consequences of cerebral blood flow and cerebral palsy (patients older than 18 years).
- Hypersensitivity to tizanidine or any other component of the preparation.
- Severe liver dysfunction.
- Concomitant use with fluvoxamine or ciprofloxacin.
Concomitant use with CYP1A2 inhibitors sirdalud not recommended.
Use in children
Experience with drug in children is limited. Application sirdalud in children is not recommended.
Use in renal failure and / or in elderly patients
In the application sirdalud in patients with renal insufficiency (creatinine clearance less than 25 mL / min) requires correction dosing regime. Experience with buy proviron online sirdalud in elderly patients is limited. Based on the pharmacokinetic data it can be assumed that in some cases the renal clearance of these patients can be significantly reduced. Caution must be exercised when applying sirdalud in patients with renal insufficiency and elderly patients. where to get steroids biomex labs reviews steroidusa